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🛡️ Stay ahead of fleas—because your cat deserves VIP protection!
Advantage II Large Cat is a vet-recommended topical flea treatment designed for cats over 9 lbs and 8 weeks old. It kills fleas within 12 hours and provides 30 days of waterproof, fragrance-free protection by targeting adult fleas, larvae, and eggs to break the flea life cycle. Easy to apply with no prescription needed, it’s the trusted choice for continuous, hassle-free flea prevention.

| ASIN | B004QN0MJQ |
| Active Ingredients | Imidacloprid, Pyriproxyfen |
| Age Range Description | 8 weeks and older |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #87 in Pet Supplies ( See Top 100 in Pet Supplies ) #1 in Cat Flea Drops |
| Brand | Advantage |
| Brand Name | Advantage |
| Customer Reviews | 4.5 out of 5 stars 81,410 Reviews |
| Dog Breed Size | Large |
| Global Trade Identification Number | 00724089202246 |
| Item Form | Drops |
| Item Type Name | Topical |
| Item Volume | 3.2 ml |
| Item Weight | 22.68 g |
| Manufacturer | Elanco US Inc |
| Manufacturer Part Number | 81520224 |
| Model Number | 86336790 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Cat |
| UPC | 727516696311 724089378774 643996929094 724089616852 724089202246 024089616853 788995790068 891962001323 |
| Unit Count | 4 Count |
| Volume | 3.2 ml |
V**R
IT WORKS! 24 hours after application and NO LIVE FLEAS.
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose.
M**Y
72 hours later, we are flea free!
My particular boy hates all oral meds and rather than fight to the death, I decided to try this based on the ratings. Parted his hair while he was snoozing, applied the treatment on his skin between his shoulders and neck, and let it do its thing. I did a thorough flea comb before applying to try and get out as many as possible, I combed him every day for the last 3 days and today we’re pulling nothing and no flea dust is visible! I’ve not noticed any side effects whatsoever, and he’s just as happy as ever. I did also treat the house with clear spray to prevent a bounce back.
K**S
READ THIS
With my review i am going to address points from reviews posted. This review is only based on my personal experiences. 1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds) 2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades. 3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten. 4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide. 5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation. You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!!
R**R
4 months to get rid of fleas so use consistently with shampoos as well.
Price is much cheaper than in store. However, it take 4 months to get rid of fleas! Inside cats that took a trip to groomer for nail trims both came home with the right flea! Ugh! Never had any fleas before and I was very diligent on using this product. I was hesitant using chemicals but the vet recommended this when not being able to go in. Cats tolerated it. Started July and took till end of November last year. Constant bathing and washing everything in the house including carpets and furniture. Everything, every room the cats went into. Always had inside cats but never fleas! Wouldn't wish them on any pet! This product seemed to work with the persistent scratching for maybe a week and then I would have to wait another month to give them another treatment. Vet did say fleas were really bad last year.
S**6
A must buy!
First time purchasing Advantage II for large and small cats. It works exactly as it says! Fleas start dying within 2 hours. Normally when I use topical flea treatments, my cat’s reaction would be squinting of the eyes, and jumping around. I was happy about that. I noticed fleas had fallen off my cats. I’ve never seen this when I used to use frontline Plus. Noticed them more because I had a white cover laid across their bedding and saw more than I needed to! Don’t get me wrong. I’ve used the white sheet before when doing flea treatments and have never seen this. I will continue to use Advantage II on all my cats from now on!
E**H
Good effective flea medication 👍
Seems to have worked perfectly my cat had little to no reaction to it besides him being confused at to what was on his head and his fleas were dropping off of him 30 mins or so after applying and his flea eggs and flea dirt disappeared and he seems relieved the itching and biting has stopped ima post a photo of him for funny:)
M**E
Fair price compared to stores
This is my go to for my cats, (I have 4). I love that it’s a 6 pack because all I seem to find in the stores that I go to are the single or 2 month supplies but I don’t want to drive all the way out to Petsmart/Petco & pay their prices for a smaller pack. This was imo, a fair price for the 6 doses. Arrived on time and well packed with the rest of my order. I also appreciate the subscribe & save option
F**L
Not Sure if This Worked on its own
Not sure if this ointment worked or not. I was able to apply to both my cats' neck but still found fleas after a few days of diligently removing a few every night. It may not be good for outdoor cats as they will tend to keep going back to the Flea source (inside the bushes in our case) but the fleas did eventually go away (I'm just not sure if it was because of me combing the fleas out and bathing them or if this topical ointment worked. I haven't had to reapply in a year so it might have had something to do with the disappearance of the fleas. Iw Ould recommend it since it doesn't hurt the cats and you definitely want to throw everything you got at the bugs to prevent them from reproducing.
Trustpilot
2 months ago
3 days ago