

🔧 Lock it down like a pro, or don’t bother at all!
LOCTITE 37421 Red Heavy Duty Threadlocker is a professional-grade adhesive trusted by OEMs and mechanics alike. Designed for large bolts and studs (≥1 inch), it bonds quickly (10-minute set, full cure in 24 hours) and withstands extreme shock, vibration, chemicals, and temperatures up to 140°F. Compatible with all metals including stainless steel and aluminum, it offers enhanced oil tolerance for superior performance. Disassembly requires heat, ensuring a secure, durable hold for critical automotive and industrial applications.









| ASIN | B0028OJAIY |
| Best Sellers Rank | #8,019 in Automotive ( See Top 100 in Automotive ) #28 in Thread Lock Sealers |
| Brand | Loctite |
| Brand Name | Loctite |
| Color | Red |
| Compatible Material | Aluminum, Stainless Steel |
| Container Type | Tube |
| Customer Reviews | 4.8 out of 5 stars 1,066 Reviews |
| Full Cure Time | 24 Hours |
| Global Trade Identification Number | 00079340374218 |
| Included Components | (1) LOCTITE 271 Threadlocker for Automotive | Red, 6 ml Tube |
| Item Form | Tube |
| Item Package Quantity | 1 |
| Item Type Name | automotive-thread-lock-sealers |
| Item Weight | 0.01 Pounds |
| Manufacturer | Loctite |
| Material | Metal-based formulation |
| Material Type | Metal-based formulation |
| Model | 37421 |
| Other Special Features of the Product | Strong |
| Special Feature | Strong |
| Specific Uses For Product | Automotive, Industrial, DIY, Furniture, Heavy-Duty |
| UPC | 079340374218 |
| Viscosity | Low viscosity |
| Volume | 6 Milliliters |
| Water Resistance Level | Water Repellent |
A**M
Works
Love the lock and unlock tip and work good as well
M**E
Cannot beat for large hardware in critical application
Red Loctite is great for big, critical hardware applications. I usually default to blue Loctite for just about all the applications I find, but this time I was replacing wheel bearings and disc brake mounts on a 1 ton pickup, so that included both big hardware AND critical applications - really don't want those working loose over the next 50,000 miles!!! That would be a heck of a surprise. As usual, very easy to use in the tube - just apply a bit to the leading edge of the threads, run the bolt in, and torque it down. Of course, removing hardware with red Loctite is no joke but there's always heat if needed! That also means that the hold is fantastic and again, shouldn't work loose until it's intentionally persuaded with force and/or heat. So ease of removal is not easy at all - but that's the point! Applying out of the tube is very easy: just open the cap and cut off a tiny edge of the nozzle, then apply just a little bit (I've learned not to apply too much - it's just unneeded). Definitely not messy either, which is fantastic. When you apply it to threads, it really clings to the threads, allowing you time to get it in place and run down to torque. But it's also just runny enough to really work its way down into the threads. So overall, if you need to make sure a big piece of critical hardware doesn't move until you absolutely need it to, there's no better option that this red Loctite!
G**T
Screws won’t budge
Used this for a rifle stock that was held on by 2 screws that would always come loose when shooting. This stuff kept it locked down with no issues. Highly recommend
T**.
Great price
This is a deal. The parts store charges this much for a little one.
M**E
He loves it!
I am a retired A.S.E. master technician and have used thread lockers many times over many years. This time I was fixing a friends revolver barrel that had come loose and was rotating. Problem solved and my buddy is once again a straight shooter.
T**S
Best Lock Tight Made
Best lock tight made.
A**L
Good product
Does the job. You better wait more than 24 hours otherwise it might not good be enough for heavy duty usage (old harley engine so a lot of vibratoins !). But I did it again and wait longer to make sure it was dry enough. It works well !
D**R
Great price
It's Loctite what can you say. It works how it should. Great price for the large bottle.
Trustpilot
2 months ago
1 month ago