B-Complex #12 - Vitamin B Complex with Choline Supplement - Supports Cellular Energy Production & a Healthy Nervous System* - Third-Party Certified - Gluten, Dairy & Soy-Free - 60 Capsules

Great product from accompanied that you can trust. I’ve only been using them a month, but I feel as though I have more energy and more mental acuity..

I have used this for years. It is a good value for the price to get natural quality and absorption in a capsule. There is no taste or smell which is good because I gag easily.

I stumbled upon this wonderful product and so glad I did! I have the C677T MTHFR mutation, as well as a COMT mutation. MTHFR converts B-12 and Folate (and other vitamins) to the active/methylated forms that can be used by the body and cross the blood brain barrier. Because I have both MTHFR and COMT mutations, it is best that I take B12 in the form of Adenosylcobalamin (along with Methylcobalamin), which this product has. I was taking Thorne Methyl Guard Plus, which has a higher potency of Methylfolate and B12 Methylcobalamin (and no Adenosylcobalamin), but noticed it made me a little irritable, edgy. So after watching a presentation by Dr. Ben Lynch (MTHFR.net) – a leader in MTHFR research - I learned that B12 Adenosylcobalamin can help reduce irritability, anger, etc. that those with COMT mutations can have when they take too much methylfolate. This supplement has helped “take the edge off” (pun intended).  This particular supplement formulation seems to work for me, my son and my father. I have noticed increased energy and mood stability and less irritability in all of us. And, as for my 90-year-old father, he was on antidepressants for 10 years (as well as on and off of them for the prior 55 years). 2014 blood work showed B12 deficiency, so he started B12 (cyanocobalamin) shots, but saw no improvement, and his antidepressants were gradually increased. In October 2015, his blood work showed he was in range for B12 and folate, but his homocysteine level was high. Because of the research I had done on MTHFR, I knew right away that my dad had an MTHFR mutation, because (1) when blood homocysteine is elevated while B12 and Folate are in the normal range, that indicates the body is not properly converting folic acid to methylated folate and B12 (cyanocobalamin-synthetic form) to methylated B12 (active forms used by the body); (2) I had to get my MTHFR mutation from a parent. The form of B12 in the shots my dad was taking monthly is cyanocobalamin, which is synthetic and cheap and requires properly working MTHFR for conversion. So keep in mind that B12 and folate levels in blood work alone is not an accurate indicator of whether or not the body is actually converting to active forms required for the body to utilize. The addition of a homocysteine test is more revealing. Since my dad started taking Thorne B Complex #12, he is completely off of antidepressants and doing well! His doctors are intrigued and impressed. I gave them the information and hope they will use it to help other patients. Every person is different. It is best to start with lower potency supplements and work your way up to prevent reactions (in my case, reaction to too much methylfolate). Dr. Ben Lynch has two MTHFR mutations himself, so he has a personal interest in this field. MTHFR.net is a FABULOUS resource for those struggling with MTHFR mutations, or those who want to find out if they have such mutations. It is now believed that at least 50% of the population has some MTHFR variant (SNPs), which can cause a host of problems, including fibromyalgia, miscarriages, severe depression, autism and much more. While there is typically not one “smoking gun” that causes all our ailments, I believe MTHFR is a good place to start. MTHFR.net can tell you which tests to have and where to get them. I hope this helps someone!

I have only taken this vitamin for 30 days but all good so far.

Disclaimer: The FDA does not evaluate dietary supplement statements, and they are not intended to diagnose, treat, cure, or prevent any disease. I am not a doctor, pharmacist, or any other medical expert. This review is not intended to diagnose, treat, cure, or prevent any illness, injury, disease, or medical condition. The intention of the review is for informational purposes only. You should consult your doctor or healthcare provider before taking any supplement(s). Dietary supplements are designed to enhance a well-balanced diet and promote a healthy lifestyle. The best ways to get vitamins, minerals, antioxidants, and to live a happy healthy lifestyle are: eating a healthy balanced diet including more vegetables and fruits, staying hydrated, exercising, weight management, stress management, not smoking, vaping, or using tobacco products, limit alcohol consumption, have a positive outlook, and get plenty of quality sleep. Supplements do not cure anything, but they may fill gaps you are missing from your diet or dietary restrictions. Remember supplements are not for everyone. Some people should avoid using supplements due to health conditions or other factors. For instance, it is unknown if certain supplements are safe to use while pregnant or breastfeeding. If you are unsure if you need to take a supplement: Consult your doctor, registered dietitian, pharmacist, or healthcare provider before starting any supplement(s). A healthcare professional will ensure that the supplements do not interfere with any prescribed medications, thus preventing potential risks or complications. Your doctor can run tests which can identify lack of vitamins, minerals, or any hormonal imbalances. During a routine blood check my doctor reported my vitamin B was low and I needed to take B-Complex supplement. I researched and tried other B-Complex supplements, and I did not feel any difference. So, I switched to Thorne B-Complex #12. Excellent B-Complex Supplement! I have been using Thorne B-Complex #12 for six months now, and I can confidently say it is one of the best B-vitamin supplements I have tried. The combination of active B12 and folate makes a noticeable difference in my energy levels and mental clarity. Additionally, during my next visit, my doctor reevaluated my blood and my vitamin B was in normal range again. I appreciate that Thorne uses high-quality ingredients without unnecessary additives. The capsules are easy to swallow, and I have not experienced any digestive discomfort, which can sometimes happen with other B-complex supplements. I also love that it is third party evaluated for purity and potency, giving me peace of mind about what I am putting into my body. What I like about the product is: 1. They use quality ingredients. 2. No digestive issues. 3. They are third party tested. What I do not like and what prevents the product from receiving a perfect 5-star rate: 1. The product is higher priced than other B-Complex supplements. If you are looking for a clean, effective B-complex supplement, I highly recommend this one!

I'm a fan of this. Helps my energy levels, helps my gut motility. It's not always necessary, and you can tell by the color of your urine after taking it. Tastes fine, isn't too big, doesn't have an off putting smell. Can't speak to it's absorption, but I can say the effects seem to work. Thorne seems like a good brand.

Thorne B-Complex #12 has been a total game-changer for my energy levels. It’s like a secret weapon for those dragging afternoons—I feel more focused and less like I need a caffeine IV to get through the day. The active forms of B12 and folate make a big difference, especially if your body struggles to process the synthetic versions found in other supplements. I also love that it’s gentle on the stomach. I’ve taken it on an empty stomach without any issues, which is rare for a B-complex. The capsules are small and easy to swallow, and there’s no weird aftertaste or bright yellow “B-vitamin pee” (if you know, you know). The only downside is the price—it’s on the premium side, but with Thorne’s reputation for quality and clean ingredients, it’s worth it. Plus, with only one capsule a day, the bottle lasts longer than you’d think. If you’re looking for a high-quality B-complex that boosts energy, supports mood, and doesn’t mess with your stomach, this is it. 4.8/5

Very good supplement

I always suffered with the Bs. I'm pushing 60 and really needed them. I did an allithiamine (B1) routine for a few months then tried this one and I could take it -- daily -- with no gut issues or misery. I really like the Thorne brand. They have a few different B complexes and only this one agrees with me.

Great product but you pay for it

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