---
product_id: 51457228
title: "Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe..."
brand: "zylkene"
price: "€ 95.73"
currency: EUR
in_stock: null
reviews_count: 13
category: "Zylkene"
url: https://www.desertcart.gr/products/51457228-zylkene-calming-supplements-for-large-dogs-15-to-60kg-450mg
store_origin: GR
region: Greece
---

# Natural milk protein (alpha casozepine) 450mg dose for large dogs 20 easy-to-administer capsules Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe...

**Brand:** zylkene
**Price:** € 95.73
**Availability:** ❌ Out of Stock

## Summary

> 🐾 Keep Calm & Carry On: Because your big buddy deserves peace of mind

## Quick Answers

- **What is this?** Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... by zylkene
- **How much does it cost?** € 95.73 with free shipping
- **Is it available?** Currently out of stock
- **Where can I buy it?** [www.desertcart.gr](https://www.desertcart.gr/products/51457228-zylkene-calming-supplements-for-large-dogs-15-to-60kg-450mg)

## Best For

- zylkene enthusiasts

## Why This Product

- Trusted zylkene brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Non-Drowsy Relaxation:** Keeps your dog calm without sedation, perfect for active lifestyles
- • **Stress Relief On-Demand:** Effective for short-term anxiety triggers like fireworks and social events
- • **Effortless Administration:** Sprinkle capsules on food for hassle-free dosing anytime, anywhere
- • **Vet-Trusted Calming Power:** UK’s No.1 vet-recommended calming supplement for large dogs
- • **Clinically Proven Natural Formula:** Harnesses alpha casozepine, a milk-derived protein with proven calming effects

## Overview

Zylkene Calming Supplements deliver 450mg of clinically proven natural milk protein to help large dogs (30-60kg) manage short-term stressors like loud noises and social situations. Trusted by vets and behaviorists across the UK, these 20 easy-to-use capsules promote non-drowsy relaxation, making them an essential for pet owners who want their dogs calm, confident, and ready for anything.

## Description

From the brand Providing the calm in the chaos for every cat and dog, wherever they go. Zylkene contains a natural milk protein with clinically proven calming effects to help support your cat and dog during challenging situations Help pets cope with challenging situations inside and outside the home: Helps ease anxiety Non-drowsy Promotes relaxation Providing the calm in the chaos for every cat and dog, wherever they go. Zylkene contains a natural milk protein with clinically proven calming effects to help support your cat and dog during challenging situations Help pets cope with challenging situations inside and outside the home Helps ease anxiety Non-drowsy Promotes relaxation Shop Zylkene Caps Visit the store Shop Zylkene Caps Visit the store Shop Zylkene Chews Visit the store Shop Zylkene Chews Shop Zylkene Plus Visit the store Shop Zylkene Plus How does Zylkene work? Zylkene calming supplement contains a natural ingredient derived from a protein in milk called casein that has clinically proven calming effects and helps comfort cats & dogs. Is Zylkene suitable for general everyday use? Zylkene is suitable for both long and short-term use. For long-term use, we recommend giving Zylkene to your pet every day for a month, then reassessing and continuing if needed. How long does Zylkene take to work? We recommend giving Zylkene 1-2 days before the predicted challenging event or when a change in their environment is expected to happen. How does Zylkene work? Zylkene calming supplement contains a natural ingredient derived from a protein in milk called casein that has clinically proven calming effects and helps comfort cats & dogs. Is Zylkene suitable for general everyday use? Zylkene is suitable for both long and short-term use. For long-term use, we recommend giving Zylkene to your pet every day for a month, then reassessing and continuing if needed. How long does Zylkene take to work? We recommend giving Zylkene 1-2 days before the predicted challenging event or when a change in their environment is expected to happen.

Review: Very good - If you have a small cat or dog who struggles with anxiety during stressful times—like thunderstorms, fireworks, or trips to the vet—these Zylkene supplements are incredibly helpful. The 75mg capsules are designed for smaller pets (up to 10kg) and use a natural milk protein derivative to promote relaxation without making them drowsy. They are easily administered—you can give them whole, or just sprinkle the powder over a small meal. They really help take the edge off and allow your pet to cope better with short-term, challenging situations. I highly recommend keeping them on hand for predictable events! It has a good price, great quality, and happy to recommend
Review: Good for Anxious Cats - 2 years ago we got another cat and have been at our wits end as him and my older cat do not get along. And the younger one was becoming quite a bully. I have recently tried these in the evening and my cat just sleeps and he never sleeps well always looking for my other cat. So literal god send means my elder can have some peace and quiet.

## Features

- Zylkene (450mg) is a calming supplement for large dogs (30 to 60kg) to help them cope with short-term challenging situations such as fireworks and social gatherings
- UK's No. 1 Veterinary Calming Supplement*, widely used and trusted by vets, behaviourists and pet owners *Kynetec market data, MAT May 2023
- Suitable for challenging situations inside and outside the home so cats & dogs can feel calm wherever they are
- Contains alpha casozepine – a natural milk protein with clinically proven calming properties
- Can easily be sprinkled on to your pet's food - absorbed internally providing action for pets in and out of the home

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00K06M9QC |
| Allergen Information | Allergen-Free |
| Batteries Included | No |
| Batteries required | No |
| Best Sellers Rank | 513 in Pet Supplies ( See Top 100 in Pet Supplies ) 24 in Relaxants & Anxiety Relief for Dogs |
| Colour | White & Blue |
| Customer Reviews | 4.1 4.1 out of 5 stars (4,184) |
| Date First Available | 24 Jun. 2014 |
| Flavor | Unflavoured |
| Item Form | Capsule |
| Item model number | 3605874361775 |
| Number of Items | 1 |
| Pet Life Stage | Adult |
| Pet Type | Cats, Dogs, Horses |
| Product Dimensions | 6 x 6 x 17 cm; 0.45 g |
| Quantity | 1 |
| Size | 20 count (Pack of 1) |
| Specific Uses | Behaviour |
| Volume | 1 |

## Product Details

- **Brand:** Zylkene
- **Flavour:** Unflavoured
- **Item form:** Capsule
- **Primary supplement type:** Casein
- **Product benefits:** Brain Health Support

## Images

![Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... - Image 1](https://m.media-amazon.com/images/I/71hWFQgX5nL.jpg)
![Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... - Image 2](https://m.media-amazon.com/images/I/71W65hGXErL.jpg)
![Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... - Image 3](https://m.media-amazon.com/images/I/71tHQqd+0yL.jpg)
![Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... - Image 4](https://m.media-amazon.com/images/I/71dUKTHJl5L.jpg)
![Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pe... - Image 5](https://m.media-amazon.com/images/I/616wZP8AcsL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: What is the best time to give**
A: Zylkene is suitable for both short- and long-term use. 
For short term use we recommend you begin administration 1 or 2 days before the predicted stressful event. For long term use, give Zylkene to your pet every day for a month then reassess their needs and continue if needed.
We recommend talking to your vet if it is a long-term problem to make sure there are no underlying issues.

We hope this information was useful! The Zylkene Team.

**Q: Why is The packaging is all in foreign?**
A: If it is a foreign supplier, I imagine the info will not be in English, I always search for UK seller.

**Q: I have a 4 month old kitten is it safe to give her these please?**
A: My kitten is 2 mouths old and my vet prescribed me this medication for him . Unfortunately I didn’t see any difference yet .

**Q: How long does it take to work?**
A: used to calm our dog before going to the groomers , started 3 days before our appointment giving 2 tablets daily . Originally prescribed by our vet and those were dosage recommended

## Customer Reviews

### ⭐⭐⭐⭐⭐ Very good
*by R***A on 22 November 2025*

If you have a small cat or dog who struggles with anxiety during stressful times—like thunderstorms, fireworks, or trips to the vet—these Zylkene supplements are incredibly helpful. The 75mg capsules are designed for smaller pets (up to 10kg) and use a natural milk protein derivative to promote relaxation without making them drowsy. They are easily administered—you can give them whole, or just sprinkle the powder over a small meal. They really help take the edge off and allow your pet to cope better with short-term, challenging situations. I highly recommend keeping them on hand for predictable events! It has a good price, great quality, and happy to recommend

### ⭐⭐⭐⭐⭐ Good for Anxious Cats
*by A***R on 22 December 2025*

2 years ago we got another cat and have been at our wits end as him and my older cat do not get along. And the younger one was becoming quite a bully. I have recently tried these in the evening and my cat just sleeps and he never sleeps well always looking for my other cat. So literal god send means my elder can have some peace and quiet.

### ⭐⭐⭐⭐ Impossible to get into a psychopath cat
*by D***. on 12 March 2023*

Heard so many good things about this, so purchased it. Impossible to get into our highly strung cat. Wasted 6 capsules trying different methods, on food, in a small amount of water syringed into her mouth (still bearing the scars from that one) on lick-e-lix, on malt paste. I’m not saying this product doesn’t work, I had every hope, but when it comes to tablets/powders and administering to cats, you’ve got a battle on your hands.

## Frequently Bought Together

- Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pet Anxiety | Helps Pets cope with short-term challenging situations | Easily administered | 20 capsules
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*Product available on Desertcart Greece*
*Store origin: GR*
*Last updated: 2026-03-02*