--- product_id: 3403144 title: "Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses | Count of 6, Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr" brand: "frontline" price: "€ 151.68" currency: EUR in_stock: true category: "Frontline" url: https://www.desertcart.gr/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea store_origin: GR region: Greece --- # Waterproof after 24h Fast-acting in hours 30-day full protection Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses | Count of 6, Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr **Brand:** frontline **Price:** € 151.68 **Availability:** ✅ In Stock ## Summary > 🛡️ Stay ahead of pests, because your dog deserves the best protection! ## Quick Answers - **What is this?** Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses | Count of 6, Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr by frontline - **How much does it cost?** € 151.68 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.gr](https://www.desertcart.gr/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea) ## Best For - frontline enthusiasts ## Why This Product - Trusted frontline brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **One Dose, One Month:** Simple monthly application covers your dog’s entire body. - • **Waterproof Protection:** Keeps working even after your dog’s swim or bath. - • **Safe for All Life Stages:** Gentle formula suitable for puppies 8 weeks+ and large breeds. - • **Break the Flea Life Cycle:** Kills adult fleas, eggs, larvae & ticks for total pest control. - • **Trusted for Over 20 Years:** Proven reliability pet owners swear by since 2001. ## Overview Frontline Plus for Dogs Large (45-88 lbs) is a fast-acting, waterproof topical flea and tick treatment that kills adult fleas, eggs, larvae, ticks, and chewing lice. Trusted by pet owners for over 20 years, it provides 30 days of continuous protection with a single monthly dose, suitable for puppies 8 weeks and older. Its dual active ingredients, fipronil and (S)-methoprene, break the flea life cycle and help control sarcoptic mange, ensuring your dog stays pest-free even after water exposure. ## Description Product Description Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention. Brand Story By Frontline Plus ## Features - The #1 name in flea and tick protection - Trusted by pet owners for over 20 years** - Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application - Protects from fleas and ticks for a full month - Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice - Aids in the control of sarcoptic mange infestations - Stops existing flea infestations and prevents establishment of new infestations ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B0002J1FOO | | ASIN | B0002J1FOO | | Active Ingredients | fipronil and (S)-methoprene | | Age Range Description | All Life Stages | | Allergen Information | Allergen-Free | | Best Sellers Rank | #1,860 in Pet Supplies ( See Top 100 in Pet Supplies ) #14 in Dog Flea Drops | | Brand Name | Frontline | | Customer Reviews | 4.5 4.5 out of 5 stars (14,002) | | Date First Available | October 2, 2001 | | Department | Pet Supplies | | Dog Breed Size | Large | | Included Components | Package includes 6 applicators | | Item Form | Liquid | | Item Type Name | Topical Purple box | | Item Weight | 4.54 g | | Item model number | 72219 | | Manufacturer | Boehringer Ingelheim Animal Health | | Manufacturer | Boehringer Ingelheim Animal Health | | Manufacturer Part Number | 605388958174 | | Model Number | 72219 | | Product Dimensions | 5.75 x 1 x 4.5 inches; 0.16 ounces | | Scent Name | Unscented | | Target Species | Dog | | UPC | 605388958174 701002620738 634252111407 794712170624 010701820043 643396060175 891962001187 897786529487 764527051814 788995790211 634252076362 350604288206 717077006667 609456799225 712542174193 609456799263 813471010955 288210000007 712542174094 | | Unit Count | 1 Count | | Volume | 1 ml | | Warranty Description | If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842 | ## Product Details - **Active Ingredients:** fipronil and (S)-methoprene - **Allergen Information:** Allergen-Free - **Brand:** Frontline - **Color:** Purple Box - **Dog Breed Size:** Large - **Item Form:** Liquid - **Item Volume:** 1 ml - **Item Weight:** 4.54 g - **Scent:** Unscented - **Unit Count:** 1 Count ## Images ![Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses | Count of 6, Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr - Image 1](https://m.media-amazon.com/images/I/711CF6-d1KL.jpg) ## Questions & Answers **Q: effectiveness** A: Ive never had a flea problem with frontline, but for ticks they would attach to the dog before it died. So i switched to the seresto 8 month collar. The 1st one i used worked great no issues. The 2nd one (8months later) had the same date as the first one. I dont know if that was an issue but the collar stopped working after 5 months and we ended up with fleas. First time that we ever had fleas. So i am going back to frontline. My concerns are the date on package and where its coming from. **Q: can i use this on my cat?** A: Hi, Thank you for your question! This specific product and formula is only intended for large dogs and puppies 45 - 88 lbs and should not be applied to cats. We have Frontline Plus for Cats 6 dose that is specifically formulated to treat your Cats & Kittens 1.5 lbs and above for 6 full months of protection. If you have any additional questions, please call our experts at 1-800-660-1842. **Q: how soon after use, can I bathe dog with shampoo** A: "FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application. "I would also wait a few extra days if there are fleas in your carpet or if the dog is around bark dust because you can't reapply it if you wash it off prematurely. I try to wait until I have vacuumed the house a few times. Also, it takes a starving flea a couple of days to die. I totally understand not wanting to touch that wet spot on puppy's neck. This is a small sacrifice. Good luck! I am a firm believer in frontline. **Q: is it a pill?** A: No, this is a topical solution not a pill. ## Frequently Bought Together - Frontline Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses - Frontline Plus for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 6 Doses - Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 6 Treatments --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.gr/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea](https://www.desertcart.gr/products/3403144-plus-for-dogs-large-dog-45-to-88-pounds-flea) --- *Product available on Desertcart Greece* *Store origin: GR* *Last updated: 2026-08-20*